Humphrey Lab

Genetics of Neurodegeneration

Current Funding


2025-2026 Pilot Grant Program (Robert Packard Center for ALS Research)
ALS patient-specific transcriptional networks and disease subtypes with multi-tissue factor analysis
 
2025-2028  Alzheimer's Disease Research Program (BrightFocus)
Identifying TDP-43 pathology burden in a mixed cohort of aging brains

2025-2028 ALS Discovery Network  (My Name’5 Doddie)
Single Cell Analysis of TDP-43 Dysfunction in ALS
PIs: Matthew Keuss (UCL), Ariana Gatt (UCL), Jack Humphrey
2025-2028 ALS Discovery Network (My Name’5 Doddie)
2024-2026 Basic Biology Consortium (Target ALS)
Investigating glial-immune crosstalk in modulating sporadic ALS survival in postmortem and longitudinal samples
PIs:  Jack Humphrey, Philip Hasel (Edinburgh), Rickie Patani (UCL), Andrea Malaspina (UCL)
2023-2025: Pipeline Grant (CurePSP)
Understanding the roles of risk loci implicated in genome-wide association studies of PSP.
PI: Kurt Farell (Mount Sinai)

Previous Funding

2023-2024: Seed Grant (ALS Association)
Mapping the genetics of TDP-43 binding in ALS motor neurons
2021-2023:  Developmental Project Funding Award (MSSM Alzheimer’s Disease Research Center)
Assessing the genetic contribution of RNA editing within myeloid cells to Alzheimer’s disease