Transcriptomic analysis of ALS/FTD postmortem tissues
As members of the New York Genome Center ALS Consortium, we have full access to all tissue RNA-seq and whole genome sequencing, and have applied it to multiple projects.
We apply cutting-edge genomics to understand neurodegeneration, including long-read, single-cell and spatial approaches.
By integrating genetic variants with molecular phenotypes, we can uncover new risk genes for disease and identify the causal mechanisms. We've applied this to postmortem spinal cord tissue in ALS, and microglia in Alzheimer's and Parkinson's disease.
We are contributors to Leafcutter, the highly-used software tool for computational analysis of mRNA splicing. We also maintain the accompanying visualization tool Leafviz.